- Slovak Name: Východoslovenské Múzeum
- Location: Hviezdoslavova Street
The East Slovak Museum is one of the oldest and largest museums in the country, dedicated to preserving and showcasing the cultural, historical, and natural heritage of the eastern Slovak region.

The museum was founded in 1872 and has a long-standing history of collecting, studying, and exhibiting artifacts and objects of cultural and scientific significance. It is housed in several buildings throughout the city. The main building is on Hviezdoslavova Street to the north of Hlávna.
The East Slovak Museum encompasses a wide range of collections, covering various disciplines and topics. Its exhibitions and displays feature archaeology, ethnography, history, art, natural history, and more.
The East Slovak Museum also organizes temporary exhibitions, educational programs, lectures, and other events to engage with the public and promote a deeper understanding of the cultural and natural heritage of the region.